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Details on Person UniProt:Q8R1G1 Tasp1
| Class:Id | ReferenceGeneProduct:88288 |
|---|---|
| _chainChangeLog | chain:1-233 added on Sat February 7 2015;chain:234-420 added on Sat February 7 2015 |
| _displayName | UniProt:Q8R1G1 Tasp1 |
| _timestamp | 2023-11-03 18:35:34 |
| chain | chain:1-233 chain:234-420 |
| checksum | 13F648362CF617C4 |
| comment | FUNCTION Protease responsible for KMT2A/MLL1 and KMT2D/MLL2 processing and activation (PubMed:16951254). Through substrate activation, it controls the expression of HOXA genes, and the expression of key cell cycle regulators including CCNA1, CCNB1, CCNE1 and CDKN2A (PubMed:16951254).SUBUNIT Intramolecular proteolysis generates 2 subunits, alpha and beta, which reassemble through a non-covalent association to form the fully active enzyme.ALTERNATIVE PRODUCTS Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.DISRUPTION PHENOTYPE Tasp1-null mice are born with no apparent respiratory distress, but the majority dies at postpartum day 1 or 2 with no obvious milk spots, suggesting a feeding defect. Newborns are smaller in size compared to their wild-type littermates. This phenotype appears in utero. Animals that survive the newborn period are markedly smaller through adulthood, and display skeletal abnormalities.SIMILARITY Belongs to the Ntn-hydrolase family. |
| description | recommendedName: Threonine aspartase 1 shortName: Taspase-1 ecNumber: 3.4.25.- component recommendedName: Threonine aspartase subunit alpha /component component recommendedName: Threonine aspartase subunit beta /component |
| geneName | Tasp1 |
| identifier | Q8R1G1 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Hydrolase Protease Reference proteome Threonine protease Zymogen |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9750299] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Tasp1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TASP1_MOUSE Q99JP3 |
| sequenceLength | 420 |
| species | [Species:48892] Mus musculus |
| (isoformParent) | [ReferenceIsoform:154686] UniProt:Q8R1G1-2 Tasp1 [Mus musculus] [ReferenceIsoform:411687] UniProt:Q8R1G1-1 Tasp1 [Mus musculus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9818642] Tasp1 [cytosol] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q8R1G1 Tasp1 (88288)
