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Details on Person UniProt:P51865 Cripto
| Class:Id | ReferenceGeneProduct:88195 |
|---|---|
| _chainChangeLog | signal peptide:1-17 added on Fri February 6 2015;chain:18-134 added on Fri February 6 2015;propeptide:135-171 added on Fri February 6 2015 |
| _displayName | UniProt:P51865 Cripto |
| _timestamp | 2025-08-15 22:17:29 |
| chain | signal peptide:1-17 chain:18-134 propeptide:135-171 |
| checksum | C53400EBACDB5380 |
| comment | FUNCTION GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by Tmem8a modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.SUBUNIT Interacts with the activin type-1 receptor ACVR1B.INTERACTION Released from the cell membrane by GPI cleavage.TISSUE SPECIFICITY Expressed at low level in specific organs of the adult animal such as spleen, heart, lung and brain. During gastrulation, expressed in the forming mesoderm. In later stages of the developing heart, expression is restricted to the truncus arteriosus.DEVELOPMENTAL STAGE First expressed prior to the onset of gastrulation (early streak stage), then continues throughout embryonic development.PTM The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (Tmem8a), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (Gpld1) into a soluble form.SIMILARITY Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. |
| description | recommendedName: Teratocarcinoma-derived growth factor alternativeName: Cripto growth factor alternativeName: Epidermal growth factor-like Cripto protein |
| geneName | Cripto Tdgf1 |
| identifier | P51865 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Disulfide bond EGF-like domain Glycoprotein GPI-anchor Growth factor Lipoprotein Membrane Reference proteome Secreted Signal |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Cripto |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | TDGF1_MOUSE Q7TQ06 |
| sequenceLength | 171 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:1181123] N-aspartyl-glycosylphosphatidylinositolethanolamine-D134-Tdgf1 [plasma membrane] [Mus musculus] |
| (referenceSequence) | [ModifiedResidue:1226044] N-aspartyl-glycosylphosphatidylinositolethanolamine at 134 |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P51865 Cripto (88195)
