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Details on Person UniProt:P19070 Cr2
| Class:Id | ReferenceGeneProduct:88121 |
|---|---|
| _chainChangeLog | signal peptide:1-11 added on Fri February 6 2015;chain:12-1025 added on Fri February 6 2015 |
| _displayName | UniProt:P19070 Cr2 |
| _timestamp | 2025-05-21 21:17:36 |
| chain | signal peptide:1-11 chain:12-1025 |
| checksum | 19E518B9A0273694 |
| comment | FUNCTION Serves as a receptor for various ligands including complement component CD3d, HNRNPU OR IFNA1. When C3d is bound to antigens, attaches to C3d on B-cell surface and thereby facilitates the recognition and uptake of antigens by B-cells. This interaction enhances B-cell activation and subsequent immune responses. Forms a complex with several partners on the surface of B-cells including CD19, FCRL5 and CD81, to form the B-cell coreceptor complex that plays a crucial role in B-cell activation and signaling. Also induces specific intracellular signaling separately from the BCR and CD19 by activating the tyrosine kinase SRC, which then phosphorylates nucleolin/NCL and triggers AKT and GSK3 kinase activities in a SYK/CD19-independent manner. Acts as a ligand for CD23 (FcepsilonRII), a low-affinity receptor for IgE, which is expressed on B-cells and other immune cells, and thus participates in the regulation of IgE production.SUBUNIT Interacts (via Sushi domain 1 and 2) with C3. Interacts with CD19. Part of a complex composed of CD19, CR2/CD21, CD81 and IFITM1/CD225 in the membrane of mature B-cells. Interacts (via Sushi domain 1 and 2) with FCER2 (via the C-terminus). Interacts with CD23. Interacts with FCRL5. Interacts with CR1. Interacts with INFNA1.SUBCELLULAR LOCATION B-lymphocytes.DISRUPTION PHENOTYPE CR2-deficient mice fail to mount an inflammatory response when compared with wild-type mice (PubMed:12421918).SIMILARITY Belongs to the receptors of complement activation (RCA) family. |
| description | recommendedName: Complement receptor type 2 shortName: Cr2 alternativeName: Complement C3d receptor cdAntigenNameCD21/cdAntigenName |
| geneName | Cr2 |
| identifier | P19070 |
| isSequenceChanged | FALSE |
| keyword | Cell membrane Complement pathway Disulfide bond Glycoprotein Immunity Innate immunity Membrane Receptor Reference proteome Repeat Signal Sushi Transmembrane Transmembrane helix |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | Cr2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CR2_MOUSE |
| sequenceLength | 1025 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9966376] Cr2 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P19070 Cr2 (88121)
