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Details on Person UniProt:O95639 CPSF4
| Class:Id | ReferenceGeneProduct:88099 |
|---|---|
| _chainChangeLog | chain:1-269 added on Sat February 7 2015 |
| _displayName | UniProt:O95639 CPSF4 |
| _timestamp | 2024-11-03 20:09:28 |
| chain | chain:1-269 |
| checksum | 49444E3EB840464A |
| comment | FUNCTION Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).SUBUNIT Component of the cleavage and polyadenylation specificity factor (CPSF) complex, composed of CPSF1, CPSF2, CPSF3, CPSF4 and FIP1L1. Interacts with FIP1L1.SUBUNIT (Microbial infection) Interacts with influenza A virus NS1 blocks processing of pre-mRNAs, thereby preventing nuclear export of host cell mRNAs.INTERACTION May be due to a competing acceptor splice site.SIMILARITY Belongs to the CPSF4/YTH1 family. |
| description | recommendedName: Cleavage and polyadenylation specificity factor subunit 4 alternativeName: Cleavage and polyadenylation specificity factor 30 kDa subunit shortName: CPSF 30 kDa subunit alternativeName: NS1 effector domain-binding protein 1 shortName: Neb-1 alternativeName: No arches homolog |
| geneName | CPSF4 CPSF30 NAR NEB1 |
| identifier | O95639 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Host-virus interaction Metal-binding mRNA processing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat RNA-binding Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CPSF4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997089] ENSEMBL:ENSG00000160917 CPSF4 [Homo sapiens] |
| secondaryIdentifier | CPSF4_HUMAN D6W5S8 Q6FGE6 Q86TF8 Q9BTW6 |
| sequenceLength | 269 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145880] UniProt:O95639-2 CPSF4 [Homo sapiens] [ReferenceIsoform:145881] UniProt:O95639-3 CPSF4 [Homo sapiens] [ReferenceIsoform:402161] UniProt:O95639-1 CPSF4 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:169104] CPSF4 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95639 CPSF4 (88099)
