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Details on Person (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2

Class:Id	Reaction:880050
_displayName	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
_doRelease	TRUE
_timestamp	2011-01-31 17:14:04
authored	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
catalystActivity	[CatalystActivity:880037] (S)-2-hydroxyglutarate dehydrogenase activity of L2HGDH [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9643344] 2-hydroxyglutarate dehydrogenase activity of L2HGDH [mitochondrial inner membrane] The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
edited	[InstanceEdit:880051] D'Eustachio, P, 2010-06-25
input	[SimpleEntity:880013] (S)-2HG [mitochondrial matrix] [SimpleEntity:113596] FAD [mitochondrial matrix]
isChimeric	FALSE
literatureReference	[LiteratureReference:880025] A gene encoding a putative FAD-dependent L-2-hydroxyglutarate dehydrogenase is mutated in L-2-hydroxyglutaric aciduria [LiteratureReference:879998] The gene mutated in l-2-hydroxyglutaric aciduria encodes l-2-hydroxyglutarate dehydrogenase [LiteratureReference:880030] L-2-Hydroxyglutaric aciduria: identification of a mutant gene C14orf160, localized on chromosome 14q22.1
modified	[InstanceEdit:941848] Garapati, P V, 2010-09-04 [InstanceEdit:996690] D'Eustachio, P, 2010-11-07 [InstanceEdit:1004538] D'Eustachio, P, 2010-11-09 [InstanceEdit:1080814] D'Eustachio, P, 2010-11-27 [InstanceEdit:1181203] D'Eustachio, P, 2011-01-31 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	(S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2
output	[SimpleEntity:113594] 2OG [mitochondrial matrix] [SimpleEntity:31649] FADH2 [mitochondrial matrix]
releaseDate	2010-12-14
reviewed	[InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:1181204] Rush, MG, 2011-01-31
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104107] R-HSA-880050.3
summation	[Summation:880036] L2HDGH associated with the mitochondrial inner membrane cata...
(hasEvent)	[Pathway:880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate [Homo sapiens]
(precedingEvent)	[Reaction:880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde [Homo sapiens]
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No pathways have been reviewed or authored by (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 (880050)