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Details on Person (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate
Class:Id Reaction:880002 _displayName (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate _doRelease TRUE _timestamp 2025-10-16 18:43:58 authored [InstanceEdit:880051] D'Eustachio, P, 2010-06-25 catalystActivity [CatalystActivity:880047] hydroxyacid-oxoacid transhydrogenase activity of ADHFE1(1-?) [mitochondrial matrix] catalystActivityReference [CatalystActivityReference:9643304] hydroxyacid-oxoacid transhydrogenase activity of ADHFE1(1-?) [mitochondrial matrix] Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias compartment [Compartment:5460] mitochondrial matrix created [InstanceEdit:880051] D'Eustachio, P, 2010-06-25 edited [InstanceEdit:880051] D'Eustachio, P, 2010-06-25 input [SimpleEntity:879997] 2HG [mitochondrial matrix] [SimpleEntity:880046] SUCCSA [mitochondrial matrix] isChimeric FALSE literatureReference [LiteratureReference:880028] Isolation and characterization of a hydroxyacid-oxoacid transhydrogenase from rat kidney mitochondria [LiteratureReference:880012] Kinetic characterization of human hydroxyacid-oxoacid transhydrogenase: relevance to D-2-hydroxyglutaric and gamma-hydroxybutyric acidurias modified [InstanceEdit:880064] D'Eustachio, P, 2010-06-26 [InstanceEdit:941848] Garapati, P V, 2010-09-04 [InstanceEdit:996690] D'Eustachio, P, 2010-11-07 [InstanceEdit:1004538] D'Eustachio, P, 2010-11-09 [InstanceEdit:1080814] D'Eustachio, P, 2010-11-27 [InstanceEdit:1181203] D'Eustachio, P, 2011-01-31 [InstanceEdit:9643047] Wu, G, 2019-04-04 [InstanceEdit:9653621] D'Eustachio, Peter, 2019-07-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9968592] D'Eustachio, Peter, 2025-10-16 name (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate negativePrecedingEvent [NegativePrecedingEvent:9968591] Futile Cycle: 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde output [SimpleEntity:113594] 2OG [mitochondrial matrix] [SimpleEntity:880041] HBUT [mitochondrial matrix] precedingEvent
releaseDate 2010-12-14 reverseReaction
reviewed [InstanceEdit:1004534] Jassal, B, 2010-11-09 [InstanceEdit:1181204] Rush, MG, 2011-01-31 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:1104532] R-HSA-880002.5 summation [Summation:880018] ADHFE1 catalyzes the reversible reaction of (R)-2-hydroxyglu... (hasEvent) [Pathway:880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate [Homo sapiens] (precedingEvent) [NegativePrecedingEvent:9968594] Futile Cycle: (R)-2-hydroxyglutarate + succinate semialdehyde <=> 2-oxoglutarate + 4-hydroxybutyrate (reverseReaction) [Reaction:880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde [Homo sapiens]
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