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Details on Person The receptor is activated

Class:Id	BlackBoxEvent:879942
_displayName	The receptor is activated
_doRelease	TRUE
_timestamp	2010-12-02 14:36:30
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:879892] Jupe, S, 2010-06-25
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[DefinedSet:913364] High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] [Homo sapiens] [DefinedSet:913364] High affinity binding complexes of interleukin receptors using the Common beta chain [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:893513] Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors [LiteratureReference:879924] Mechanism of activation of the GM-CSF, IL-3, and IL-5 family of receptors
modified	[InstanceEdit:893547] Jupe, S, 2010-07-01 [InstanceEdit:909735] Jupe, S, 2010-07-07 [InstanceEdit:913398] Jupe, S, 2010-07-14 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:941871] Jupe, S, 2010-09-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	The receptor is activated
output	[DefinedSet:913399] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 [Homo sapiens] [Reaction:450074] Interleukin-3 receptor alpha subunit binds Interleukin-3 [Homo sapiens] [Reaction:879937] The common beta chain IL3RB binds JAK2 [Homo sapiens] [Reaction:913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 [Homo sapiens] [Reaction:913456] Interleukin-5 receptor alpha subunit binds Interleukin-5 [Homo sapiens] [Reaction:879937] The common beta chain IL3RB binds JAK2 [Homo sapiens] [Reaction:913371] GM-CSF receptor alpha:GM-CSF binds Bc [Homo sapiens] [Reaction:913360] GM-CSF receptor alpha subunit binds GM-CSF [Homo sapiens] [Reaction:879937] The common beta chain IL3RB binds JAK2 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104903] R-HSA-879942.2
summation	[Summation:879946] Upon ligand binding to the alpha subunit, the alpha and Bc s...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)	[Reaction:879907] Tyrosine kinases phosphorylate the receptor [Homo sapiens] [Reaction:879910] JAK2 is phosphorylated, activated [Homo sapiens] [BlackBoxEvent:879923] SRC is activated [Homo sapiens] [Reaction:913451] IL3RB is phosphorylated on Ser-585 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9790021] Update Tracker - [BlackBoxEvent:879942] The receptor is activated - v35:[modifyText]
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