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Details on Person Recruitment of SHC1 is mediated by Y593 of the common beta chain

Class:Id	Reaction:879934
_displayName	Recruitment of SHC1 is mediated by Y593 of the common beta chain
_doRelease	TRUE
_timestamp	2010-12-02 14:39:41
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:879892] Jupe, S, 2010-06-25
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[DefinedSet:913422] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:74680] SHC1 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:909750] Evidence for a physical association between the Shc-PTB domain and the beta c chain of the granulocyte-macrophage colony-stimulating factor receptor [LiteratureReference:507926] New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
modified	[InstanceEdit:904809] Jupe, S, 2010-07-02 [InstanceEdit:909735] Jupe, S, 2010-07-07 [InstanceEdit:912307] Jupe, S, 2010-07-08 [InstanceEdit:912541] Jupe, S, 2010-07-09 [InstanceEdit:913398] Jupe, S, 2010-07-14 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:939140] Jupe, S, 2010-08-31 [InstanceEdit:941871] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Recruitment of SHC1 is mediated by Y593 of the common beta chain
output	[DefinedSet:913458] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:879907] Tyrosine kinases phosphorylate the receptor [Homo sapiens] [BlackBoxEvent:879942] The receptor is activated [Homo sapiens] [Reaction:913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 [Homo sapiens] [Reaction:913371] GM-CSF receptor alpha:GM-CSF binds Bc [Homo sapiens] [Reaction:450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105505] R-HSA-879934.2
summation	[Summation:904799] Upon receptor activation, Shc is recruited to the receptor c...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)	[Reaction:879925] SHC1 bound to the common beta chain becomes tyrosine phosphorylated [Homo sapiens]
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