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Details on Person SHC1 bound to the common beta chain becomes tyrosine phosphorylated

Class:Id	Reaction:879925
_displayName	SHC1 bound to the common beta chain becomes tyrosine phosphorylated
_doRelease	TRUE
_timestamp	2010-12-02 14:36:05
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:912324] protein tyrosine kinase activity of Unknown tyrosine kinase [cytosol]
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:879892] Jupe, S, 2010-06-25
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[DefinedSet:913458] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:909736] Formation of Shc-Grb2 complexes is necessary to induce neoplastic transformation by overexpression of Shc proteins [LiteratureReference:913436] Tyrosine phosphorylation of Shc is induced by IL-3, IL-5 and GM-CSF [LiteratureReference:909746] A novel pathway from phosphorylation of tyrosine residues 239/240 of Shc, contributing to suppress apoptosis by IL-3
modified	[InstanceEdit:904809] Jupe, S, 2010-07-02 [InstanceEdit:909735] Jupe, S, 2010-07-07 [InstanceEdit:912307] Jupe, S, 2010-07-08 [InstanceEdit:912323] Jupe, S, 2010-07-08 [InstanceEdit:912541] Jupe, S, 2010-07-09 [InstanceEdit:913398] Jupe, S, 2010-07-14 [InstanceEdit:914066] Jupe, S, 2010-07-21 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:941871] Jupe, S, 2010-09-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SHC1 bound to the common beta chain becomes tyrosine phosphorylated
output	[DefinedSet:913439] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p-(Y593,628)-Bc:p(427,349,350)-SHC1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:879934] Recruitment of SHC1 is mediated by Y593 of the common beta chain [Homo sapiens] [Reaction:879907] Tyrosine kinases phosphorylate the receptor [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104821] R-HSA-879925.2
summation	[Summation:909742] IL-3, IL-5 and GM-CSF all induce tyrosine phosphorylation of...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:453104] Phosphorylated SHC1 recruits GRB2:GAB2 [Homo sapiens] [Reaction:453111] Phosphorylated SHC recruits GRB2:SOS1 [Homo sapiens] [Reaction:879891] Phosphorylated Shc binds to Grb2 in the Grb2:Gab2 complex [Homo sapiens] [Reaction:913374] Phosphorylated SHC1 recruits SHIP [Homo sapiens]
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