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Details on Person CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated

Class:Id	Reaction:879917
_displayName	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
_doRelease	TRUE
_timestamp	2010-12-02 14:33:31
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:879892] Jupe, S, 2010-06-25
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[EntityWithAccessionedSequence:112199] CBL [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] [Homo sapiens] [DefinedSet:508248] p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens] [CandidateSet:912625] FYN-like kinases [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:912630] CBL-GRB2 interaction in myeloid immunoreceptor tyrosine activation motif signaling [LiteratureReference:912560] The proto-oncogene product c-Cbl becomes tyrosine phosphorylated by stimulation with GM-CSF or Epo and constitutively binds to the SH3 domain of Grb2/Ash in human hematopoietic cells [LiteratureReference:912561] Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase [LiteratureReference:912650] Phosphorylation of cbl after stimulation of Nb2 cells with prolactin and its association with phosphatidylinositol 3-kinase
modified	[InstanceEdit:912563] Jupe, S, 2010-07-09 [InstanceEdit:912661] Jupe, S, 2010-07-12 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:941868] Jupe, S, 2010-09-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated
output	[Complex:912623] FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104354] R-HSA-879917.2
summation	[Summation:912638] Cbl is constitutively associated with Grb2 in resting hemato...
(hasEvent)	[Pathway:912631] Regulation of signaling by CBL [Homo sapiens]
(precedingEvent)	[Reaction:912629] CBL is tyrosine phosphorylated [Homo sapiens]
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No pathways have been reviewed or authored by CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (879917)