Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person JAK2 is phosphorylated, activated

Class:Id	Reaction:879910
_displayName	JAK2 is phosphorylated, activated
_doRelease	TRUE
_timestamp	2010-12-02 14:35:51
authored	[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity	[CatalystActivity:914083] non-membrane spanning protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:879892] Jupe, S, 2010-06-25
edited	[InstanceEdit:927712] Jupe, S, 2010-08-06
input	[DefinedSet:913399] High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:873856] Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop [LiteratureReference:879936] JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region
modified	[InstanceEdit:893547] Jupe, S, 2010-07-01 [InstanceEdit:904809] Jupe, S, 2010-07-02 [InstanceEdit:909735] Jupe, S, 2010-07-07 [InstanceEdit:912300] Jupe, S, 2010-07-08 [InstanceEdit:913398] Jupe, S, 2010-07-14 [InstanceEdit:914066] Jupe, S, 2010-07-21 [InstanceEdit:927713] Jupe, S, 2010-08-06 [InstanceEdit:941868] Jupe, S, 2010-09-06 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	JAK2 is phosphorylated, activated
output	[DefinedSet:913405] High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[BlackBoxEvent:879942] The receptor is activated [Homo sapiens] [Reaction:450031] Interleukin-3 receptor alpha: Interleukin-3 binds IL3RB:JAK2 [Homo sapiens] [Reaction:913370] Interleukin-5:Interleukin-5 receptor alpha binds IL3RB:JAK2 [Homo sapiens] [Reaction:913371] GM-CSF receptor alpha:GM-CSF binds Bc [Homo sapiens]
releaseDate	2010-09-21
reviewed	[InstanceEdit:941869] Lopez, AF, 2010-09-06 [InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104784] R-HSA-879910.2
summation	[Summation:879955] JAK2 is tyrosine phosphorylated in response to IL-3 (Silvenn...
(hasEvent)	[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)	[Reaction:879930] STAT5 is recruited by JAK2 [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9789986] Update Tracker - [Reaction:879910] JAK2 is phosphorylated, activated - v36:[modifyText]
[Change default viewing format]

No pathways have been reviewed or authored by JAK2 is phosphorylated, activated (879910)