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Details on Person Activation of STAT5a/b by JAK2

Class:IdReaction:879909
_displayNameActivation of STAT5a/b by JAK2
_doReleaseTRUE
_timestamp2010-12-02 14:37:15
authored[InstanceEdit:744679] Ray, KP, 2010-05-17
catalystActivity[CatalystActivity:912315] protein tyrosine kinase activity of High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane]
compartment[Compartment:70101] cytosol
[Compartment:876] plasma membrane
created[InstanceEdit:879892] Jupe, S, 2010-06-25
edited[InstanceEdit:927712] Jupe, S, 2010-08-06
input[DefinedSet:913447] High affinity binding complex dimers of cytokine receptors using Bc. activated JAK2:STAT5 [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:904797] In vitro interaction between STAT 5 and JAK 2; dependence upon phosphorylation status of STAT 5 and JAK 2
modified[InstanceEdit:904809] Jupe, S, 2010-07-02
[InstanceEdit:912300] Jupe, S, 2010-07-08
[InstanceEdit:912307] Jupe, S, 2010-07-08
[InstanceEdit:913398] Jupe, S, 2010-07-14
[InstanceEdit:927713] Jupe, S, 2010-08-06
[InstanceEdit:941868] Jupe, S, 2010-09-06
[InstanceEdit:1043153] Wu, G, 2010-11-19
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivation of STAT5a/b by JAK2
output[DefinedSet:913465] High affinity binding complex dimers of cytokine receptors using Bc, activated JAK2:p-STAT5 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
releaseDate2010-09-21
reviewed[InstanceEdit:941869] Lopez, AF, 2010-09-06
[InstanceEdit:941867] Hercus, TR, 2010-09-06
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105015] R-HSA-879909.2
summation[Summation:879949] JAK2 phosphorylates STAT5; phosphorylated STAT5 dimerizes an...
(hasEvent)[Pathway:512988] Interleukin-3, Interleukin-5 and GM-CSF signaling [Homo sapiens]
(precedingEvent)[Reaction:921155] p-STAT5 dissociates from the receptor complex [Homo sapiens]
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