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Details on Person Expression of DEC2 (BHLHE41, BHLHB3)

Class:IdBlackBoxEvent:879770
_displayNameExpression of DEC2 (BHLHE41, BHLHB3)
_doReleaseTRUE
_timestamp2025-06-02 14:48:51
authored[InstanceEdit:879784] May, B, 2010-06-18
compartment[Compartment:7660] nucleoplasm
created[InstanceEdit:879757] May, B, 2010-06-23
edited[InstanceEdit:879784] May, B, 2010-06-18
inferredFrom
input[EntityWithAccessionedSequence:5641212] BHLHE41 gene [nucleoplasm] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:1368871] Molecular cloning and characterization of DEC2, a new member of basic helix-loop-helix proteins
[LiteratureReference:9909541] DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
modified[InstanceEdit:927716] May, B, 2010-08-06
[InstanceEdit:1368921] May, B, 2011-06-30
[InstanceEdit:5641233] May, Bruce, 2014-11-16
[InstanceEdit:5663195] May, Bruce, 2015-01-15
[InstanceEdit:9606200] Wu, G, 2018-04-19
[InstanceEdit:9641190] Wu, G, 2019-04-04
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
[InstanceEdit:9940986] May, Bruce, 2025-03-06
[InstanceEdit:9953423] May, Bruce, 2025-06-02
nameExpression of DEC2 (BHLHE41, BHLHB3)
output[EntityWithAccessionedSequence:879703] BHLHE41 [nucleoplasm] [Homo sapiens]
precedingEvent
previousReviewStatus[ReviewStatus:9821384] two stars
regulatedBy[PositiveGeneExpressionRegulation:879843] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:BHLHE41 gene [nucleoplasm]'
[NegativeGeneExpressionRegulation:9909568] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]'
regulationReference[RegulationReference:9642601] Positive gene expression regulation by 'p-BMAL1:p-CLOCK,NPAS2:BHLHE41 gene [nucleoplasm]' Expression of the gene for Dec2, a basic helix-loop-helix transcription factor, is regulated by a molecular clock system
[RegulationReference:9909559] Negative gene expression regulation by 'BHLHE40 dimer [nucleoplasm]' DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter
releaseDate2010-09-21
reviewed[InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22
[InstanceEdit:879756] Albrecht, Urs, 2010-06-23
[InstanceEdit:879726] Kay, SA, 2010-06-23
[InstanceEdit:879790] Hirota, T, 2010-06-23
[InstanceEdit:879786] Delaunay, F, 2010-06-23
[InstanceEdit:9953422] Albrecht, Urs, 2025-03-07
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1105199] R-HSA-879770.5
structureModified[InstanceEdit:9940986] May, Bruce, 2025-03-06
summation[Summation:879751] The DEC2 (BHLHE41, BHLHB3) gene is transcribed to yield mRNA...
(hasEvent)[Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian expression [Homo sapiens]
(updatedInstance)[_UpdateTracker:9785458] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v52:[add_removeRegulator]
[_UpdateTracker:9785917] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v51:[addInput]
[_UpdateTracker:9786974] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v46:[modifyText]
[_UpdateTracker:9789249] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v38:[addLiteratureReference]
[_UpdateTracker:9953555] Update Tracker - [BlackBoxEvent:879770] Expression of DEC2 (BHLHE41, BHLHB3) - v93:[removeLiteratureReference, removeRegulator]
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