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Details on Person Expression of PPARA

Class:Id	BlackBoxEvent:879724
_displayName	Expression of PPARA
_doRelease	TRUE
_timestamp	2025-07-21 16:37:58
authored	[InstanceEdit:879784] May, B, 2010-06-18
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:879757] May, B, 2010-06-23
edited	[InstanceEdit:879784] May, B, 2010-06-18
goBiologicalProcess	[GO_BiologicalProcess:17788] positive regulation of transcription by RNA polymerase II
inferredFrom	[BlackBoxEvent:879764] Expression of Ppara [Mus musculus]
input	[EntityWithAccessionedSequence:5640195] PPARA gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1368864] Human and rat peroxisome proliferator activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators [LiteratureReference:561153] Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human
modified	[InstanceEdit:927716] May, B, 2010-08-06 [InstanceEdit:1368921] May, B, 2011-06-30 [InstanceEdit:1989744] May, B, 2011-11-13 [InstanceEdit:5640212] May, Bruce, 2014-11-16 [InstanceEdit:5663195] May, Bruce, 2015-01-15 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9940986] May, Bruce, 2025-03-06 [InstanceEdit:9960253] D'Eustachio, Peter, 2025-07-08 [InstanceEdit:9961204] D'Eustachio, Peter, 2025-07-21
name	Expression of PPARA
output	[EntityWithAccessionedSequence:400186] PPARA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:5663156] p-S90-BMAL1:p-T451,T461-CLOCK binds PPARA gene [Homo sapiens] [BlackBoxEvent:9920665] p-S90-BMAL1:p-T451,T461-CLOCK translocates from the cytosol to the nucleus [Homo sapiens] [BlackBoxEvent:400143] Fatty acid ligands activate PPARA [Homo sapiens] [BlackBoxEvent:400183] PPARA:RXRA binds Corepressors of PPARA [Homo sapiens] [Reaction:2026996] FABP1 transports fatty acids into the nucleus [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:879833] Positive gene expression regulation by 'p-S90-BMAL1:p-T451,T461-CLOCK:PPARA gene [nucleoplasm]' [PositiveGeneExpressionRegulation:1989805] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]'
regulationReference	[RegulationReference:9641251] Positive gene expression regulation by 'PPARA:RXRA Coactivator complex [nucleoplasm]' Comparative analysis of gene regulation by the transcription factor PPARalpha between mouse and human [RegulationReference:9642007] Positive gene expression regulation by 'p-BMAL1:p-CLOCK,NPAS2:PPARA gene [nucleoplasm]' CLOCK is involved in the circadian transactivation of peroxisome-proliferator-activated receptor alpha (PPARalpha) in mice
releaseDate	2010-09-21
reviewed	[InstanceEdit:422151] D'Eustachio, P, 2009-05-26 22:13:22 [InstanceEdit:879756] Albrecht, Urs, 2010-06-23 [InstanceEdit:879726] Kay, SA, 2010-06-23 [InstanceEdit:879790] Hirota, T, 2010-06-23 [InstanceEdit:879786] Delaunay, F, 2010-06-23 [InstanceEdit:425906] Kersten, S, 2009-06-08 [InstanceEdit:9940981] Albrecht, Urs, 2025-03-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104709] R-HSA-879724.6
summation	[Summation:879711] The PPARA gene is transcribed to yield mRNA and the mRNA is ...
(hasEvent)	[Pathway:1368108] BMAL1:CLOCK,NPAS2 activates circadian expression [Homo sapiens] [Pathway:1989781] PPARA activates gene expression [Homo sapiens]
(precedingEvent)	[Reaction:400204] PPARA binds RXRA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9775654] Update Tracker - [BlackBoxEvent:879724] Expression of PPARA - v78:[modifyText] [_UpdateTracker:9785227] Update Tracker - [BlackBoxEvent:879724] Expression of PPARA - v52:[add_removeRegulator] [_UpdateTracker:9785778] Update Tracker - [BlackBoxEvent:879724] Expression of PPARA - v51:[addInput] [_UpdateTracker:9787074] Update Tracker - [BlackBoxEvent:879724] Expression of PPARA - v46:[modifyText] [_UpdateTracker:9788945] Update Tracker - [BlackBoxEvent:879724] Expression of PPARA - v39:[addLiteratureReference, addRegulator] [_UpdateTracker:9789475] Update Tracker - [BlackBoxEvent:879724] Expression of PPARA - v38:[addLiteratureReference]
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No pathways have been reviewed or authored by Expression of PPARA (879724)