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Details on Person Three organic anion transporting polypeptides (OATPs; now ca...
| Class:Id | Summation:879548 |
|---|---|
| _displayName | Three organic anion transporting polypeptides (OATPs; now ca... |
| _timestamp | 2025-09-24 08:27:55 |
| created | [InstanceEdit:879538] Jassal, Bijay, 2010-06-18 |
| modified | [InstanceEdit:908579] Jassal, Bijay, 2010-07-07 [InstanceEdit:5661189] Jassal, Bijay, 2015-01-09 [InstanceEdit:8875603] Jassal, Bijay, 2016-06-08 [InstanceEdit:8879091] Jassal, Bijay, 2016-07-15 [InstanceEdit:9965916] Stephan, Ralf, 2025-09-08 [InstanceEdit:9966643] Stephan, Ralf, 2025-09-24 |
| text | Three organic anion transporting polypeptides (OATPs; now called solute carrier organic anion transporters, SLCOs) are able to mediate the transport of thyroid hormones, predominantly thyroxine (T4) and triiodothyronine (T3) (Fujiwara et al. 2001). SLCO1B1 (formerly OATP-C), which can also transport bile salts, is mainly expressed in the liver (Abe et al. 1999; Hsiang et al. 1999). SLCO4A1 (formerly OATP-E) is mainly expressed in peripheral tissue and has a broad substrate specificty (Lofthouse et al., 2018). SLCO1C1 (formerly OATP-F) is highly expressed in brain and is also a high affinity thyroid hormone transporter (Pizzagalli et al. 2002). The monocarboxylate transporter 8 (MCT8, SLC16A2 is also a very active and specific thyroid hormone transporter in its dimeric form (Visser et al. 2009). Defects in SLC16A2 can cause severe X-linked psychomotor retardation. SLC16A2 mutations that inhibite SLC16A2 dimerisation result in defective transport function of SLC16A2 (Fischer et al. 2015). |
| (summation) | [Reaction:879575] SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol [Homo sapiens] |
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