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Details on Person In addition to AGER/RAGE, several other proteins have been i...

Class:IdSummation:879431
_displayNameIn addition to AGER/RAGE, several other proteins have been i...
_timestamp2010-07-06 15:49:40
created[InstanceEdit:879462] Jupe, S, 2010-06-17
literatureReference[LiteratureReference:879486] Two novel rat liver membrane proteins that bind advanced glycosylation endproducts: relationship to macrophage receptor for glucose-modified proteins
[LiteratureReference:879468] Molecular identity and cellular distribution of advanced glycation endproduct receptors: relationship of p60 to OST-48 and p90 to 80K-H membrane proteins
[LiteratureReference:879490] Identification of galectin-3 as a high-affinity binding protein for advanced glycation end products (AGE): a new member of the AGE-receptor complex
[LiteratureReference:879352] Characterization of the advanced glycation end-product receptor complex in human vascular endothelial cells
[LiteratureReference:879488] Advanced glycation endproduct (AGE) receptor 1 is a negative regulator of the inflammatory response to AGE in mesangial cells
modified[InstanceEdit:879497] Jupe, S, 2010-06-18
[InstanceEdit:908577] Jupe, S, 2010-07-06
textIn addition to AGER/RAGE, several other proteins have been identified as AGE-binding proteins. AGE binding proteins p60 and p90 (Yang et al. 1991) were subsequently identified as the Oligosaccharyl transferase 48 kDa subunit (Ost-48) and Glucosidease-2 subunit beta (Li et al. 1996). A third member was identified as Galectin-3 (Vlassara et al. 1995). These 3 proteins have been shown to be present on the plasma membrane of many cell types including vascular endothelium (Stitt et al. 1999). They have been designated AGE-R1, -R2 and -R3. Their suggested function is the removal and degradation of AGEs, but AGER-1 was found to negatively regulate AGER/RAGE (Lu et al. 2004), with kinetics that suggested a more complex interaction than simple competition for the same ligand.
(summation)[Reaction:879358] AGER-1,2,3 bind AGEs [Homo sapiens]
[Reaction:879372] Ager-1,2,3 bind AGEs [Rattus norvegicus]
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