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Details on Person Advanced glycosylation end product specific receptor (AGER) ...

Class:IdSummation:879391
_displayNameAdvanced glycosylation end product specific receptor (AGER) ...
_timestamp2010-11-09 10:16:07
created[InstanceEdit:879462] Jupe, S, 2010-06-17
literatureReference[LiteratureReference:879426] Understanding RAGE, the receptor for advanced glycation end products
[LiteratureReference:879470] N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for receptor for advanced glycation end products that activate cell signaling pathways and modulate gene expression
[LiteratureReference:879465] N (epsilon)-(carboxymethyl)lysine protein adduct is a major immunological epitope in proteins modified with advanced glycation end products of the Maillard reaction
[LiteratureReference:879403] RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
[LiteratureReference:879371] Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer's disease
[LiteratureReference:879447] RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides
[LiteratureReference:879374] The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin. Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
modified[InstanceEdit:908577] Jupe, S, 2010-07-06
[InstanceEdit:997391] Jupe, S, 2010-11-09
textAdvanced glycosylation end product specific receptor (AGER) also known as Receptor for advanced glycation end products (RAGE) is a multi-ligand membrane receptor belonging to the immunoglobulin superfamily. It recognizes a large variety of modified proteins known as advanced glycation/glycosylation endproducts (AGEs) a heterogenous group of structures (Ikeda et al. 1996) that accumulate in patients with diabetes, atherosclerosis, renal failure or ageing (Schmidt et al. 1999). The most prevalent class of AGE in vivo are N(6)-carboxymethyllysine (NECML) adducts (Kislinger et al. 1991). AGER is a receptor for amyloid-beta peptide (Ab)(Yan et al. 1996), mediating Ab neurotoxicity and promoting Ab influx into the brain (Zhang et al. 2009). AGER also responds to the proinflammatory S100/calgranulins (Hofmann et al. 1999) and High mobility group protein B1 (HMGB1/Amphoterin/DEF) (Hori et al. 1995). The major pathway is NFkappaB activation, but AGER can also activate rho-GTPases and thereby MAPK and JNK cascades. (Bierhaus et al. 2005).
(summation)[Reaction:879411] Advanced glycosylation end product-specific receptor (AGER/RAGE) is a multiligand receptor [Homo sapiens]
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