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Details on Person Proline-serine-threonine phosphatase-interacting protein 1 (...
| Class:Id | Summation:879186 |
|---|---|
| _displayName | Proline-serine-threonine phosphatase-interacting protein 1 (... |
| _timestamp | 2011-05-20 15:07:34 |
| created | [InstanceEdit:879225] Jupe, S, 2010-06-15 |
| literatureReference | [LiteratureReference:1250286] A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion [LiteratureReference:879199] Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants [LiteratureReference:1296416] Inflammasomes and their activation |
| modified | [InstanceEdit:1250252] Jupe, S, 2011-04-15 [InstanceEdit:1296413] Jupe, S, 2011-05-20 |
| text | Proline-serine-threonine phosphatase-interacting protein 1 (PSTPIP1) is a pyrin-binding protein, involved in regulation of the actin cytoskeleton (Li et al. 1998) and suggested as a regulator of inflammasome activation (Khare et al. 2010). A naturally occurring mutation of PSTPIP1 where Y344 is replaced by F blocks tyrosine phosphorylation and reduces pyrin binding. Mutations of PSTPIP1 that increase pyrin binding are associated with the inflammatory syndrome pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA). Expression of PSTPIP1 with these mutations in THP-11 cells resulted in substantially increased caspase-1 activation and IL-1beta secretion. PSTPIP1 binding to pyrin is believed to promote the unmasking of its PYD domain and enhance interactions with ASC, facilitating ASC oligomerization and caspase-1 recruitment (Yu et al. 2007). |
| (summation) | [Reaction:879221] PSTPIP1 binds Pyrin [Homo sapiens] |
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No pathways have been reviewed or authored by Proline-serine-threonine phosphatase-interacting protein 1 (... (879186)
