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Details on Person dsDNA:AIM2:ASC cluster binds procaspase-1

Class:Id	Reaction:877388
_displayName	dsDNA:AIM2:ASC cluster binds procaspase-1
_doRelease	TRUE
_timestamp	2011-06-10 08:44:25
authored	[InstanceEdit:1253354] Jupe, S, 2011-04-28
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:877390] Jupe, S, 2010-06-14
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
input	[Complex:877397] dsDNA:Aim2 oligomer:Asc [cytosol] [Mus musculus] [EntityWithAccessionedSequence:877398] Procaspase-1 [cytosol] [Mus musculus]
isChimeric	FALSE
literatureReference	[LiteratureReference:874032] AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA [LiteratureReference:874003] AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
modified	[InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1254262] Jupe, S, 2011-04-28 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	dsDNA:AIM2:ASC cluster binds procaspase-1
output	[Complex:877387] dsDNA:Aim2 oligomer:Asc:Procaspase-1 [cytosol] [Mus musculus]
precedingEvent	[Reaction:877385] dsDNA:Aim2 clusters bind Asc [Mus musculus]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus
stableIdentifier	[StableIdentifier:1357570] R-MMU-877388.2
summation	[Summation:873990] The ASC CARD domain recruits procaspase-1 leading to autoact...
(inferredFrom)	[Reaction:844618] dsDNA:AIM2:ASC cluster binds procaspase-1 [Homo sapiens]
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No pathways have been reviewed or authored by dsDNA:AIM2:ASC cluster binds procaspase-1 (877388)