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Details on Person Trimeric pyrin interacts with ASC through its Pyrin domains,...
| Class:Id | Summation:877367 |
|---|---|
| _displayName | Trimeric pyrin interacts with ASC through its Pyrin domains,... |
| _timestamp | 2010-06-15 14:20:47 |
| created | [InstanceEdit:877366] Jupe, S, 2010-06-14 |
| literatureReference | [LiteratureReference:879208] Targeted disruption of pyrin, the FMF protein, causes heightened sensitivity to endotoxin and a defect in macrophage apoptosis [LiteratureReference:879199] Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants |
| modified | [InstanceEdit:879225] Jupe, S, 2010-06-15 |
| text | Trimeric pyrin interacts with ASC through its Pyrin domains, leading to oligomerization of ASC. This interaction interferes with the ability of NLRP3 (Cyropyrin) to associate with ASC and thus inhibits inflammasome activation (Chae et al. 2003). |
| (summation) | [Reaction:877361] Pyrin binds ASC [Homo sapiens] |
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No pathways have been reviewed or authored by Trimeric pyrin interacts with ASC through its Pyrin domains,... (877367)
