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Details on Person Dephosphorylation of JAKs by PTPs

Class:Id	Reaction:877308
_displayName	Dephosphorylation of JAKs by PTPs
_doRelease	TRUE
_timestamp	2018-01-02 20:37:53
authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
catalystActivity	[CatalystActivity:997306] protein tyrosine phosphatase activity of PTPs-SHP1/2/PTP1B [cytosol]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:877278] Garapati, P V, 2010-06-11
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
inferredFrom	[Reaction:877301] Dephosphorylation of Jaks by Ptps [Mus musculus]
input	[Complex:873820] IFNG:IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane] [Homo sapiens] [SimpleEntity:29356] H2O [cytosol]
isChimeric	FALSE
modified	[InstanceEdit:933346] Garapati, P V, 2010-08-10 [InstanceEdit:933763] Garapati, P V, 2010-08-17 [InstanceEdit:941856] Garapati, P V, 2010-09-06 [InstanceEdit:994080] Garapati, P V, 2010-11-05 [InstanceEdit:997305] Garapati, P V, 2010-11-08 [InstanceEdit:998146] Garapati, P V, 2010-11-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9034197] Orlic-Milacic, Marija, 2018-01-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Dephosphorylation of JAKs by PTPs
output	[SimpleEntity:29372] Pi [cytosol] [SimpleEntity:29372] Pi [cytosol] [Complex:873829] IFNG:IFNGR1:JAK1:IFNGR2:JAK2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:873918] Transphosphorylation of JAK1 [Homo sapiens] [Reaction:873919] Phosphorylation of JAK2 [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105108] R-HSA-877308.3
summation	[Summation:877298] Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regu...
(hasEvent)	[Pathway:877312] Regulation of IFNG signaling [Homo sapiens]
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No pathways have been reviewed or authored by Dephosphorylation of JAKs by PTPs (877308)