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Details on Person Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regu...
| Class:Id | Summation:877298 |
|---|---|
| _displayName | Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regu... |
| _timestamp | 2010-11-09 13:21:43 |
| created | [InstanceEdit:877278] Garapati, P V, 2010-06-11 |
| literatureReference | [LiteratureReference:877305] Direct association with and dephosphorylation of Jak2 kinase by the SH2-domain-containing protein tyrosine phosphatase SHP-1 |
| modified | [InstanceEdit:997283] Garapati, P V, 2010-11-08 [InstanceEdit:997420] Garapati, P V, 2010-11-09 |
| text | Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regulate the IFNG signaling by dephosphorylating the tyrosine residues critical to the activation of JAK kinases. PTP1B interacts directly with JAK2 but not JAK1 and dephosphorylate the tyrosine Y1007 on JAK2. |
| (summation) | [Reaction:877301] Dephosphorylation of Jaks by Ptps [Mus musculus] [Reaction:877308] Dephosphorylation of JAKs by PTPs [Homo sapiens] |
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No pathways have been reviewed or authored by Protein tyrosine phosphatases (PTPs) SHP1 and SHP2 down regu... (877298)
