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Details on Person PIAS1 binds p-STAT1 dimer

Class:Id	Reaction:877281
_displayName	PIAS1 binds p-STAT1 dimer
_doRelease	TRUE
_timestamp	2018-01-02 20:37:53
authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:877278] Garapati, P V, 2010-06-11
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
input	[Complex:873824] p-STAT1 homodimer [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:877307] PIAS1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:877304] SUMO1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:208336] Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction [LiteratureReference:877303] PIAS proteins as regulators of small ubiquitin-related modifier (SUMO) modifications and transcription [LiteratureReference:877311] PIAS proteins promote SUMO-1 conjugation to STAT1
modified	[InstanceEdit:933346] Garapati, P V, 2010-08-10 [InstanceEdit:933763] Garapati, P V, 2010-08-17 [InstanceEdit:941856] Garapati, P V, 2010-09-06 [InstanceEdit:994080] Garapati, P V, 2010-11-05 [InstanceEdit:998147] Garapati, P V, 2010-11-09 [InstanceEdit:1039227] Garapati, P V, 2010-11-18 [InstanceEdit:1112700] Jupe, S, 2010-12-10 [InstanceEdit:9034197] Orlic-Milacic, Marija, 2018-01-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	PIAS1 binds p-STAT1 dimer
output	[Complex:877297] p-STAT1 dimer:PIAS:SUMO1 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:873917] Translocation of STAT1 dimer to nucleus [Homo sapiens] [Reaction:873927] Release of STAT1 dimer from active receptor unit [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1105677] R-HSA-877281.3
summation	[Summation:877271] PIAS1 protein interacts directly with phoshorylated STAT1 di...
(hasEvent)	[Pathway:877312] Regulation of IFNG signaling [Homo sapiens]
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No pathways have been reviewed or authored by PIAS1 binds p-STAT1 dimer (877281)