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Details on Person PIAS1 protein interacts directly with phoshorylated STAT1 di...
| Class:Id | Summation:877271 |
|---|---|
| _displayName | PIAS1 protein interacts directly with phoshorylated STAT1 di... |
| _timestamp | 2010-11-08 18:45:37 |
| created | [InstanceEdit:877278] Garapati, P V, 2010-06-11 |
| modified | [InstanceEdit:877328] Garapati, P V, 2010-06-14 [InstanceEdit:997283] Garapati, P V, 2010-11-08 |
| text | PIAS1 protein interacts directly with phoshorylated STAT1 dimers and inhibit the transcriptional activity of STAT1 by blocking the DNA-binding domain of STAT1. It has also been suggested that PIAS proteins might regulate transcription by promoting small ubiquitin-related modifier (SUMO1) conjugation of STAT1. The significance of STAT1 sumoylation in regulating STAT1 activity is controversial and needs to be clarified. |
| (summation) | [Reaction:877281] PIAS1 binds p-STAT1 dimer [Homo sapiens] |
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No pathways have been reviewed or authored by PIAS1 protein interacts directly with phoshorylated STAT1 di... (877271)
