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Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

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Details on Person SOCS-1 and SOCS-3 [cytosol]

Class:IdDefinedSet:877267
_displayNameSOCS-1 and SOCS-3 [cytosol]
_timestamp2010-12-02 14:45:41
compartment[Compartment:70101] cytosol
created[InstanceEdit:877268] Garapati, P V, 2010-06-11
hasMember
modified[InstanceEdit:877278] Garapati, P V, 2010-06-11
nameSOCS-1 and SOCS-3
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:1106749] R-HSA-877267.1
(activeUnit)[NegativeRegulation:877306] Negative regulation by 'IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane]'
[NegativeRegulation:912708] Negative regulation by 'p-TYK2:p-IFNAR1:SOCS-1/SOCS-3:IFNA/B:IFNAR2:p-JAK1:STAT2 [plasma membrane]'
[NegativeRegulation:9707970] Negative regulation by 'SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane]'
(hasComponent)[Complex:873821] IFNG:IFNGR1:JAK1:IFNGR2:p-JAK2:SOCS-1/-3 [plasma membrane] [Homo sapiens]
[Complex:912684] p-IFNAR1:p-TYK2:SOCS-1/SOCS-3 [plasma membrane] [Homo sapiens]
[Complex:976147] RBX1-CUL5-EloB/C-SOCS [cytosol] [Homo sapiens]
[Complex:9705439] SOCS1,3:p-4Y-CSF3R:CSF3dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [plasma membrane] [Homo sapiens]
[Complex:9705731] SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [endocytic vesicle membrane] [Homo sapiens]
(input)[Reaction:877269] SOCS-1 and SOCS-3 binds to p-JAK2 [Homo sapiens]
[Reaction:912680] Inhibition of JAK kinase activity by SOCS1/3 [Homo sapiens]
[Reaction:9705467] SOCS1,3 binds p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 [Homo sapiens]
(output)[BlackBoxEvent:9705738] SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [Homo sapiens]
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No pathways have been reviewed or authored by SOCS-1 and SOCS-3 [cytosol] (877267)
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