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Details on Person P2X7 mediates membrane pores that include pannexin-1

Class:Id	BlackBoxEvent:877198
_displayName	P2X7 mediates membrane pores that include pannexin-1
_doRelease	TRUE
_timestamp	2024-05-23 01:17:13
authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:877211] Jupe, S, 2010-06-11
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
input	[Complex:877257] ATP:P2X7 oligomer [plasma membrane] [Homo sapiens] [Complex:9855178] PANX1 heptamer [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:877222] ATP induces nucleotide permeability in rat mast cells [LiteratureReference:877251] ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells [LiteratureReference:874011] Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor [LiteratureReference:9892586] P2X7 receptor-Pannexin1 complex: pharmacology and signaling
modified	[InstanceEdit:925457] Jupe, S, 2010-08-06 [InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1361858] Jupe, S, 2011-06-06 [InstanceEdit:1361865] Jupe, S, 2011-06-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9892589] May, Bruce, 2024-03-28 [InstanceEdit:9910909] May, Bruce, 2024-05-23
name	P2X7 mediates membrane pores that include pannexin-1
output	[Complex:877242] ATP:P2X7 oligomer:PANX1 heptamer [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:877158] P2X7 forms oligomeric non-selective cation channels [Homo sapiens] [Reaction:877178] ATP binds to P2X7 [Homo sapiens]
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2011-06-14
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06 [InstanceEdit:9910908] May, Bruce, 2024-05-23
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357665] R-HSA-877198.3
structureModified	[InstanceEdit:9892589] May, Bruce, 2024-03-28
summation	[Summation:877185] At higher concentrations of extracellular ATP, the P2X7 chan...
(hasEvent)	[Pathway:844456] The NLRP3 inflammasome [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:844440] NLRP3 activation by elicitor proteins [Homo sapiens] [BlackBoxEvent:1306876] NLRP3 activation by small molecules [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9911008] Update Tracker - [BlackBoxEvent:877198] P2X7 mediates membrane pores that include pannexin-1 - v89:[addLiteratureReference, add_removeInput]
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No pathways have been reviewed or authored by P2X7 mediates membrane pores that include pannexin-1 (877198)