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Details on Person P2X7 mediates loss of intracellular K+

Class:Id	Reaction:877187
_displayName	P2X7 mediates loss of intracellular K+
_doRelease	TRUE
_timestamp	2011-06-10 08:46:34
authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
catalystActivity	[CatalystActivity:877259] extracellularly ATP-gated monoatomic cation channel activity of ATP:P2X7 oligomer [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:877211] Jupe, S, 2010-06-11
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
input	[SimpleEntity:29804] K+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:877233] Nucleotide receptors: an emerging family of regulatory molecules in blood cells [LiteratureReference:877164] Purinoceptor-operated cationic channels in human B lymphocytes
modified	[InstanceEdit:925457] Jupe, S, 2010-08-06 [InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1306842] Jupe, S, 2011-05-27 [InstanceEdit:1361858] Jupe, S, 2011-06-06 [InstanceEdit:1361865] Jupe, S, 2011-06-06 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	P2X7 mediates loss of intracellular K+
output	[SimpleEntity:74126] K+ [extracellular region]
precedingEvent	[Reaction:877158] P2X7 forms oligomeric non-selective cation channels [Homo sapiens] [Reaction:877178] ATP binds to P2X7 [Homo sapiens]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357621] R-HSA-877187.2
summation	[Summation:877238] Low level or transient activation of P2X7 leads to reversibl...
(hasEvent)	[Pathway:844456] The NLRP3 inflammasome [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:844440] NLRP3 activation by elicitor proteins [Homo sapiens] [BlackBoxEvent:1306876] NLRP3 activation by small molecules [Homo sapiens]
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No pathways have been reviewed or authored by P2X7 mediates loss of intracellular K+ (877187)