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Details on Person UniProt:Q62398 Cnga2
| Class:Id | ReferenceGeneProduct:87711 |
|---|---|
| _chainChangeLog | chain:1-664 added on Fri February 6 2015 |
| _displayName | UniProt:Q62398 Cnga2 |
| _timestamp | 2024-08-09 19:00:03 |
| chain | chain:1-664 |
| checksum | 34F8DF3B372C0D9C |
| comment | FUNCTION Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations.CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)CATALYTIC ACTIVITY NH4(+)(in) = NH4(+)(out)CATALYTIC ACTIVITY Rb(+)(in) = Rb(+)(out)CATALYTIC ACTIVITY Li(+)(in) = Li(+)(out)CATALYTIC ACTIVITY Cs(+)(in) = Cs(+)(out)SUBUNIT The olfactory cyclic nucleotide-gated channel is an heterotetramer composed of CNGA2, CNGA4 and CNGB1b subunits with 2:1:1 stoichiometry.SUBCELLULAR LOCATION The C-terminal coiled-coil domain mediates trimerization of CNGA subunits.SIMILARITY Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. CNGA2 subfamily.CAUTION It is uncertain whether Met-1 or Met-2 is the initiator. |
| description | recommendedName: Cyclic nucleotide-gated channel alpha-2 shortName: CNG channel alpha-2 shortName: CNG-2 shortName evidence="7"CNG2 alternativeName: Olfactory cyclic nucleotide-gated channel subunit 1 shortName evidence="7"OCNC1 |
| geneName | Cnga2 Cncg2 Cncg4 |
| identifier | Q62398 |
| isSequenceChanged | FALSE |
| keyword | Calcium Calcium channel Calcium transport Calmodulin-binding cAMP cAMP-binding Cell membrane Cell projection cGMP cGMP-binding Coiled coil Ion channel Ion transport Ligand-gated ion channel Membrane Nucleotide-binding Olfaction Reference proteome Sensory transduction Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | Cnga2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CNGA2_MOUSE Q80XH6 |
| sequenceLength | 664 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:9713722] Cnga2 [plasma membrane] [Mus musculus] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q62398 Cnga2 (87711)
