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Details on Person UniProt:Q9BPX3 NCAPG
| Class:Id | ReferenceGeneProduct:87700 |
|---|---|
| _chainChangeLog | chain:1-1015 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BPX3 NCAPG |
| _timestamp | 2024-11-03 20:04:48 |
| chain | chain:1-1015 |
| checksum | D9ACC205C48F3AF5 |
| comment | FUNCTION Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.SUBUNIT Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.INTERACTION In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.TISSUE SPECIFICITY Highly expressed in testis.PTM Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPH subunits, activates the condensin complex and is required for chromosome condensation (By similarity).MISCELLANEOUS Overexpressed in some cancer lines and some tumor cells.SIMILARITY Belongs to the CND3 (condensin subunit 3) family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Condensin complex subunit 3 alternativeName: Chromosome-associated protein G alternativeName: Condensin subunit CAP-G shortName: hCAP-G alternativeName: Melanoma antigen NY-MEL-3 alternativeName: Non-SMC condensin I complex subunit G alternativeName: XCAP-G homolog |
| geneName | NCAPG CAPG NYMEL3 |
| identifier | Q9BPX3 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell cycle Cell division Chromosome Cytoplasm DNA condensation Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NCAPG |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990036] ENSEMBL:ENSG00000109805 NCAPG [Homo sapiens] |
| secondaryIdentifier | CND3_HUMAN Q3MJE0 Q96SV9 Q9BUR3 Q9BVY1 Q9H914 Q9H9Z6 Q9HBI9 |
| sequenceLength | 1015 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1638136] NCAPG [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2517883] p-T308,T332-NCAPG [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2529007] p-S-NCAPG [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2517879] O-phospho-L-threonine at 308 [ModifiedResidue:2525921] O-phospho-L-threonine at 332 [ModifiedResidue:2529009] O-phospho-L-serine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q9BPX3 NCAPG (87700)
