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Details on Person UniProt:Q15003 NCAPH
| Class:Id | ReferenceGeneProduct:87696 |
|---|---|
| _chainChangeLog | chain:1-741 added on Sat February 7 2015 |
| _displayName | UniProt:Q15003 NCAPH |
| _timestamp | 2024-11-03 20:13:47 |
| chain | chain:1-741 |
| checksum | B5B34A36CAE0C28E |
| comment | FUNCTION Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (PubMed:11136719). Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).SUBUNIT Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG.INTERACTION In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.ALTERNATIVE PRODUCTS Widely expressed at low level. Expressed in proliferating cells.PTM Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CND2 (condensin subunit 2) family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: Condensin complex subunit 2 alternativeName: Barren homolog protein 1 alternativeName: Chromosome-associated protein H shortName: hCAP-H alternativeName: Non-SMC condensin I complex subunit H alternativeName: XCAP-H homolog |
| geneName | NCAPH BRRN BRRN1 CAPH KIAA0074 |
| identifier | Q15003 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Chromosome Cytoplasm Disease variant DNA condensation Isopeptide bond Mitosis Nucleus Phosphoprotein Primary microcephaly Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NCAPH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999979] ENSEMBL:ENSG00000121152 NCAPH [Homo sapiens] |
| secondaryIdentifier | CND2_HUMAN B4E189 Q8TB87 |
| sequenceLength | 741 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970441] UniProt:Q15003-1 NCAPH [Homo sapiens] [ReferenceIsoform:8970442] UniProt:Q15003-2 NCAPH [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:1638139] NCAPH [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2517885] p-T-NCAPH [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:2529017] p-S570-NCAPH [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:2517886] O-phospho-L-threonine at unknown position [ModifiedResidue:2529013] O-phospho-L-serine at 570 |
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No pathways have been reviewed or authored by UniProt:Q15003 NCAPH (87696)
