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Details on Person UniProt:Q8TB37 NUBPL
| Class:Id | ReferenceGeneProduct:87682 |
|---|---|
| _chainChangeLog | transit peptide:1-38 added on Sat February 7 2015;chain:39-319 added on Sat February 7 2015 |
| _displayName | UniProt:Q8TB37 NUBPL |
| _timestamp | 2024-11-03 19:52:56 |
| chain | transit peptide:1-38 chain:39-319 |
| checksum | 7A497482A4D449A4 |
| comment | FUNCTION Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:19752196). May deliver one or more Fe-S clusters to complex I subunits (PubMed:19752196).COFACTOR Binds 1 [4Fe-4S] cluster.INTERACTION Highest expression in liver and kidney. expressed at significant levels in small intestine and brain (at protein level).DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS May be due to exon skipping.SIMILARITY Belongs to the Mrp/NBP35 ATP-binding proteins family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: fullName evidence="8"Iron-sulfur cluster transfer protein NUBPL alternativeName: IND1 homolog alternativeName: Nucleotide-binding protein-like alternativeName: huInd1 |
| geneName | NUBPL C14orf127 |
| identifier | Q8TB37 |
| isSequenceChanged | FALSE |
| keyword | 4Fe-4S Alternative splicing ATP-binding Disease variant Iron Iron-sulfur Metal-binding Mitochondrion Nucleotide-binding Primary mitochondrial disease Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NUBPL |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962526] ENSEMBL:ENSG00000151413 NUBPL [Homo sapiens] |
| secondaryIdentifier | NUBPL_HUMAN B4DHZ1 Q86TZ4 Q9H9M2 |
| sequenceLength | 319 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145743] UniProt:Q8TB37-2 NUBPL [Homo sapiens] [ReferenceIsoform:411806] UniProt:Q8TB37-1 NUBPL [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:5689133] NUBPL [mitochondrial matrix] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q8TB37 NUBPL (87682)
