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Details on Person SGT1:HSP90 binds inactive NLRP3

Class:Id	Reaction:873951
_displayName	SGT1:HSP90 binds inactive NLRP3
_doRelease	TRUE
_timestamp	2020-11-09 05:24:08
authored	[InstanceEdit:622270] Jupe, S, 2010-04-22
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:874056] Jupe, S, 2010-06-09
edited	[InstanceEdit:1253354] Jupe, S, 2011-04-28
input	[EntityWithAccessionedSequence:561189] NLRP3 [cytosol] [Homo sapiens] [Complex:874112] SUGT1:HSP90 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:874000] A crucial function of SGT1 and HSP90 in inflammasome activity links mammalian and plant innate immune responses [LiteratureReference:9706709] Hsp90 inhibition as a means to inhibit activation of the NLRP3 inflammasome
modified	[InstanceEdit:874110] Jupe, S, 2010-06-10 [InstanceEdit:925457] Jupe, S, 2010-08-06 [InstanceEdit:1253356] Jupe, S, 2011-04-28 [InstanceEdit:1361858] Jupe, S, 2011-06-06 [InstanceEdit:1361865] Jupe, S, 2011-06-06 [InstanceEdit:9673431] Murillo, Julieth, 2020-01-07 [InstanceEdit:9706708] Shamovsky, Veronica, 2020-11-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SGT1:HSP90 binds inactive NLRP3
output	[Complex:874086] NLRP3:SUGT1:HSP90 [cytosol] [Homo sapiens]
precedingEvent	[Reaction:874087] SGT1 binds HSP90 [Homo sapiens]
releaseDate	2011-06-14
reviewed	[InstanceEdit:1253355] Kufer, TA, 2011-04-28 [InstanceEdit:1361863] Rittinger, K, 2011-06-06 [InstanceEdit:1361862] Wong, Edmond, 2011-06-06
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1357501] R-HSA-873951.4
summation	[Summation:874021] SGT1 and HSP90 bind the NLRP3 (NALP3) LRR domain. Genetic s...
(hasEvent)	[Pathway:844456] The NLRP3 inflammasome [Homo sapiens] [Pathway:9660826] Purinergic signaling in leishmaniasis infection [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:844440] NLRP3 activation by elicitor proteins [Homo sapiens] [BlackBoxEvent:1306876] NLRP3 activation by small molecules [Homo sapiens] [BlackBoxEvent:9771253] NLRP3 activation by mtDNA [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9776629] Update Tracker - [Reaction:873951] SGT1:HSP90 binds inactive NLRP3 - v75:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by SGT1:HSP90 binds inactive NLRP3 (873951)