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Details on Person Phosphorylation of STAT1 by JAK kinases

Class:Id	Reaction:873922
_displayName	Phosphorylation of STAT1 by JAK kinases
_doRelease	TRUE
_timestamp	2017-07-12 18:14:50
authored	[InstanceEdit:873929] Garapati, P V, 2010-06-08
catalystActivity	[CatalystActivity:873928] protein tyrosine kinase activity of STAT1 bound to p-IFNGR1 [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:873929] Garapati, P V, 2010-06-08
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
input	[SimpleEntity:113592] ATP [cytosol] [SimpleEntity:113592] ATP [cytosol] [Complex:873828] STAT1 bound to p-IFNGR1 [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:873892] A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma [LiteratureReference:873904] Phosphorylation and activation of the DNA binding activity of purified Stat1 by the Janus protein-tyrosine kinases and the epidermal growth factor receptor [LiteratureReference:873845] Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state [LiteratureReference:933486] A road map for those who don't know JAK-STAT
modified	[InstanceEdit:913528] Garapati, P V, 2010-07-16 [InstanceEdit:933346] Garapati, P V, 2010-08-10 [InstanceEdit:933519] Garapati, P V, 2010-08-16 [InstanceEdit:933763] Garapati, P V, 2010-08-17 [InstanceEdit:941856] Garapati, P V, 2010-09-06 [InstanceEdit:994080] Garapati, P V, 2010-11-05 [InstanceEdit:998147] Garapati, P V, 2010-11-09 [InstanceEdit:1043153] Wu, G, 2010-11-19 [InstanceEdit:9012335] D'Eustachio, Peter, 2017-07-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylation of STAT1 by JAK kinases
output	[SimpleEntity:29370] ADP [cytosol] [SimpleEntity:29370] ADP [cytosol] [Complex:873817] p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:873921] Binding of STAT1 to p-IFNGR1 [Homo sapiens] [Reaction:873924] Phosphorylation of IFNGR1 by JAK kinases [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104364] R-HSA-873922.3
summation	[Summation:873848] STAT1 pair recruited to the receptor complex is phosphorylat...
(hasEvent)	[Pathway:877300] Interferon gamma signaling [Homo sapiens]
(precedingEvent)	[Reaction:909552] Phosphorylation of STAT1 at Ser727 [Homo sapiens]
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No pathways have been reviewed or authored by Phosphorylation of STAT1 by JAK kinases (873922)