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Details on Person p-STAT1 homodimer [nucleoplasm]

Class:Id	Complex:873824
_displayName	p-STAT1 homodimer [nucleoplasm]
_timestamp	2021-05-31 11:52:42
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:873801] Garapati, P V, 2010-06-08
hasComponent	[EntityWithAccessionedSequence:873792] p-S727,Y701-STAT1-1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:873792] p-S727,Y701-STAT1-1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:877268] Garapati, P V, 2010-06-11 [InstanceEdit:933464] Garapati, P V, 2010-08-16 [InstanceEdit:9732719] Orlic-Milacic, Marija, 2021-05-31
name	p-STAT1 homodimer IFNG-activated factor (GAF)
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1108789] R-HSA-873824.2
(activeUnit)	[PositiveRegulation:1031722] Positive regulation by 'GAF bound to GAS promoter element [nucleoplasm]' [PositiveGeneExpressionRegulation:9942672] Positive gene expression regulation by 'p-STAT1:NFATC1:TBX21 gene [nucleoplasm]'
(hasComponent)	[Complex:877297] p-STAT1 dimer:PIAS:SUMO1 [nucleoplasm] [Homo sapiens] [Complex:1031710] GAF bound to GAS promoter element [nucleoplasm] [Homo sapiens] [Complex:9942500] p-Y693-STAT4 dimer:p-STAT1 dimer:NFATC1:TBX21 gene [nucleoplasm] [Homo sapiens] [Complex:9942715] p-STAT1:NFATC1:TBX21 gene [nucleoplasm] [Homo sapiens]
(input)	[Reaction:877281] PIAS1 binds p-STAT1 dimer [Homo sapiens] [Reaction:997326] Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP [Homo sapiens] [Reaction:1031713] GAF binds the GAS promoter elements in the IFNG-regulated genes [Homo sapiens] [Reaction:9942683] p-STAT1 and NFATC1 bind the TBX21 gene [Homo sapiens]
(output)	[BlackBoxEvent:873917] Translocation of STAT1 dimer to nucleus [Homo sapiens]
(regulator)	[PositiveGeneExpressionRegulation:9730974] Positive gene expression regulation by 'p-STAT1 homodimer [nucleoplasm]'
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No pathways have been reviewed or authored by p-STAT1 homodimer [nucleoplasm] (873824)