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Details on Person UniProt:P59242 Cgn
Class:Id
ReferenceGeneProduct:87374
_chainChangeLog
chain:1-1191 added on Sat February 7 2015
_displayName
UniProt:P59242 Cgn
_timestamp
2023-11-03 15:25:49
chain
chain:1-1191
checksum
43EA20F49AF5E7D9
comment
FUNCTION Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.SUBUNIT Homodimer (By similarity). Interacts with TJP1/ZO1 and SPEF1 (By similarity).SUBCELLULAR LOCATION Localizes to the apical junction complex composed of tight and adherens junction (PubMed:15292197). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (By similarity).ALTERNATIVE PRODUCTS Lung, kidney and intestine.DOMAIN Deletion of the TJP1/ZO1 interaction motif (ZIM) decreases but does not abolish colocalization with TJP1/ZO1.SIMILARITY Belongs to the cingulin family.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Truncated C-terminus.SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
