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Details on Person UniProt:O96020 CCNE2
| Class:Id | ReferenceGeneProduct:87228 |
|---|---|
| _chainChangeLog | chain:1-404 added on Fri February 6 2015 |
| _displayName | UniProt:O96020 CCNE2 |
| _timestamp | 2025-02-21 19:46:15 |
| chain | chain:1-404 |
| checksum | D7DC9BEEF3FD62EC |
| comment | FUNCTION Essential for the control of the cell cycle at the late G1 and early S phase.SUBUNIT Interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.INTERACTION According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.INDUCTION Activated by papilloma viral oncoproteins E6 and E7 which bind to and inactivate p53 and Rb, respectively.PTM Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.PTM Lactylated at Lys-348 (PubMed:36896611). Delactylated by SIRT3 (PubMed:36896611).SIMILARITY Belongs to the cyclin family. Cyclin E subfamily. |
| description | recommendedName: G1/S-specific cyclin-E2 |
| geneName | CCNE2 |
| identifier | O96020 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Cyclin Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | CCNE2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001664] ENSEMBL:ENSG00000175305 CCNE2 [Homo sapiens] |
| secondaryIdentifier | CCNE2_HUMAN O95439 |
| sequenceLength | 404 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145364] UniProt:O96020-2 CCNE2 [Homo sapiens] [ReferenceIsoform:402207] UniProt:O96020-1 CCNE2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68367] CCNE2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:157452] CCNE2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6813844] Unfolded CCNE2 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O96020 CCNE2 (87228)
