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Details on Person UniProt:P24864 CCNE1
| Class:Id | ReferenceGeneProduct:87225 |
|---|---|
| _chainChangeLog | chain:1-410 added on Sat February 7 2015 |
| _displayName | UniProt:P24864 CCNE1 |
| _timestamp | 2024-11-03 19:44:57 |
| chain | chain:1-410 |
| checksum | 424DF0B253B7047E |
| comment | FUNCTION Essential for the control of the cell cycle at the G1/S (start) transition.SUBUNIT Interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex (PubMed:15660127). Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1 (PubMed:15178429). Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation (PubMed:21952639). Interacts with INCA1 (PubMed:21540187).INTERACTION Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.PTM Phosphorylation of both Thr-395 by GSK3 and Ser-399 by CDK2 creates a high affinity degron recognized by FBXW7, and accelerates degradation via the ubiquitin proteasome pathway. Phosphorylation at Thr-77 creates a low affinity degron also recognized by FBXW7.PTM Ubiquitinated by UHRF2; appears to occur independently of phosphorylation.MISCELLANEOUS Lacks 49 residues within the cyclin box and cannot complex with CDK2.SIMILARITY Belongs to the cyclin family. Cyclin E subfamily. |
| description | recommendedName: G1/S-specific cyclin-E1 |
| geneName | CCNE1 CCNE |
| identifier | P24864 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Cyclin Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CCNE1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961837] ENSEMBL:ENSG00000105173 CCNE1 [Homo sapiens] |
| secondaryIdentifier | CCNE1_HUMAN A8K684 Q14091 Q8NFG1 Q92501 Q9UD21 |
| sequenceLength | 410 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145363] UniProt:P24864-2 CCNE1 [Homo sapiens] [ReferenceIsoform:403426] UniProt:P24864-1 CCNE1 [Homo sapiens] [ReferenceIsoform:424454] UniProt:P24864-3 CCNE1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68363] CCNE1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:157443] CCNE1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6813836] Unfolded CCNE1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P24864 CCNE1 (87225)
