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Details on Person UniProt:P20248 CCNA2
| Class:Id | ReferenceGeneProduct:87208 |
|---|---|
| _chainChangeLog | chain:1-432 added on Fri February 6 2015 |
| _displayName | UniProt:P20248 CCNA2 |
| _timestamp | 2025-08-15 21:13:28 |
| chain | chain:1-432 |
| checksum | 97763A2897DD35F4 |
| comment | FUNCTION Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.SUBUNIT Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:1312467, PubMed:7630397, PubMed:8684460, PubMed:8756328). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2) (PubMed:1312467). Interacts with CDK2; the interaction increases from G1 to G2 (PubMed:1312467). Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm (PubMed:17698606). Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with INCA1 (PubMed:21540187).SUBUNIT (Microbial infection) Interacts with human cytomegalovirus protein UL32.INTERACTION Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606).DEVELOPMENTAL STAGE Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level).PTM Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome (PubMed:21596315). Deubiquitinated and stabilized by USP37 enables entry into S phase (PubMed:21596315). Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation (PubMed:31413110).SIMILARITY Belongs to the cyclin family. Cyclin AB subfamily. |
| description | recommendedName: fullName evidence="20"Cyclin-A2 shortName evidence="18"Cyclin-A alternativeName: fullName evidence="18"Cyclin A |
| geneName | CCNA2 CCN1 CCNA |
| identifier | P20248 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Cell cycle Cell division Cyclin Cytoplasm Host-virus interaction Mitosis Nucleus Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CCNA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8964579] ENSEMBL:ENSG00000145386 CCNA2 [Homo sapiens] |
| secondaryIdentifier | CCNA2_HUMAN A8K7B6 Q2M3U6 Q4W5P4 Q6LER8 |
| sequenceLength | 432 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:68905] CCNA2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:157444] CCNA2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:264429] CCNA2 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:6783099] PolyUb-CCNA2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9929512] p-S154-CCNA2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9929551] p-S154-CCNA2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6783111] ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position [ModifiedResidue:9929516] O-phospho-L-serine at 154 |
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No pathways have been reviewed or authored by UniProt:P20248 CCNA2 (87208)
