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Details on Person UniProt:P78396 CCNA1
| Class:Id | ReferenceGeneProduct:87205 |
|---|---|
| _chainChangeLog | chain:1-465 added on Sat February 7 2015 |
| _displayName | UniProt:P78396 CCNA1 |
| _timestamp | 2025-08-15 21:13:27 |
| chain | chain:1-465 |
| checksum | C9C023EEA1CF036D |
| comment | FUNCTION May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.SUBUNIT Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 (PubMed:15159402, PubMed:21540187). Interacts with KLHDC9 (PubMed:15159402).INTERACTION Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.DEVELOPMENTAL STAGE Expression increases in early G1 phase and reaches highest levels during the S and G2/M phases.PTM Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome (PubMed:21596315). Deubiquitinated and stabilized by USP37 enables entry into S phase (PubMed:21596315). Ubiquitinated during the G1 phase by the SCF(FBXO31) complex, leading to its proteasomal degradation (PubMed:31413110).SIMILARITY Belongs to the cyclin family. Cyclin AB subfamily. |
| description | recommendedName: Cyclin-A1 |
| geneName | CCNA1 |
| identifier | P78396 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell cycle Cell division Cyclin Mitosis Nucleus Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CCNA1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961889] ENSEMBL:ENSG00000133101 CCNA1 [Homo sapiens] |
| secondaryIdentifier | CCNA1_HUMAN B7Z7E3 Q5T3V0 Q5U0G2 Q8IY91 |
| sequenceLength | 465 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:384629] UniProt:P78396-2 CCNA1 [Homo sapiens] [ReferenceIsoform:404828] UniProt:P78396-1 CCNA1 [Homo sapiens] [ReferenceIsoform:8968219] UniProt:P78396-3 CCNA1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68891] CCNA1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:157446] CCNA1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:264412] CCNA1 [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:6783068] PolyUb-CCNA1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9929513] p-S183-CCNA1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9929540] p-S183-CCNA1 [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:6783048] ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position [ModifiedResidue:9929525] O-phospho-L-serine at 183 |
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No pathways have been reviewed or authored by UniProt:P78396 CCNA1 (87205)
