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Details on Person UniProt:Q9P032 NDUFAF4
| Class:Id | ReferenceGeneProduct:87148 |
|---|---|
| _chainChangeLog | chain:1-175 added on Sat February 7 2015;chain:1-175 removed on Fri February 12 2016;initiator methionine:1 added on Fri February 12 2016;chain:2-175 added on Fri February 12 2016;initiator methionine:1 for 87148 removed on Fri Nov 03 2023;initiator methionine: for 87148 added on Fri Nov 03 2023;initiator methionine: for 87148 removed on Fri Aug 15 2025;initiator methionine:1 for 87148 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9P032 NDUFAF4 |
| _timestamp | 2025-08-15 22:09:59 |
| chain | initiator methionine:1 chain:2-175 |
| checksum | B6445B0B4AA905D0 |
| comment | FUNCTION Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.SUBUNIT Binds calmodulin. Interacts with NDUFAF3.SUBUNIT (Microbial infection) Interacts with the vesicular stomatitis virus matrix protein/M; the interaction inhibits viral propagation.INTERACTION Expression is low in quiescent cells and is induced in exponentially proliferating cultures. Expression is also induced when prolactin is added to stationary cells. Induced by dietary differentiating agents such as butyrate and retinoic acid.PTM Phosphorylated on serine. Prolactin stimulate serine phosphorylation (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the NDUFAF4 family. |
| description | recommendedName: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 alternativeName: fullName evidence="9"Hormone-regulated proliferation-associated protein of 20 kDa |
| geneName | NDUFAF4 C6orf66 HRPAP20 HSPC125 My013 |
| identifier | Q9P032 |
| isSequenceChanged | FALSE |
| keyword | Calmodulin-binding Disease variant Host-virus interaction Lipoprotein Membrane Mitochondrion Myristate Phosphoprotein Primary mitochondrial disease Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | NDUFAF4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9000180] ENSEMBL:ENSG00000123545 NDUFAF4 [Homo sapiens] |
| secondaryIdentifier | NDUF4_HUMAN B2R4J5 |
| sequenceLength | 175 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5689124] NDUFAF4 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9P032 NDUFAF4 (87148)
