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Details on Person UniProt:P41209 Cetn1
Class:Id
ReferenceGeneProduct:87127
_chainChangeLog
chain:1-172 added on Fri February 6 2015;chain:1-172 removed on Fri November 4 2016;initiator methionine:1 added on Fri November 4 2016;chain:2-172 added on Fri November 4 2016
_displayName
UniProt:P41209 Cetn1
_timestamp
2024-08-09 19:46:38
chain
chain:1-172
checksum
45ABF106F58E4B60
comment
FUNCTION Plays a fundamental role in microtubule-organizing center structure and function (By similarity). Plays a role in sperm cilia formation (PubMed:27530713).SUBUNIT Monomer (By similarity). Interacts with CIMAP3 (PubMed:20643351). Interacts with USP49 (By similarity).SUBCELLULAR LOCATION Centrosome of interphase and mitotic cells. In the retinal photoreceptor cells, localizes at the connecting cilium, a thin bridge linking the cell body and the light-sensing outer segment (PubMed:30120214).TISSUE SPECIFICITY Expressed in testis. Localizes to the caudal portion of spermatozoa in seminiferous tubule and epididymis (PubMed:10486202). Expressed in retina photoreceptor cells (at protein level) (PubMed:30120214).DEVELOPMENTAL STAGE First expressed at 14 days postpartum (dpp). Levels increase dramatically between 14 dpp and 17 dpp.MISCELLANEOUS Binds two moles of calcium per mole of protein.SIMILARITY Belongs to the centrin family.
