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Details on Person UniProt:O75419 CDC45
| Class:Id | ReferenceGeneProduct:86785 |
|---|---|
| _chainChangeLog | chain:1-566 added on Sat February 7 2015 |
| _displayName | UniProt:O75419 CDC45 |
| _timestamp | 2024-11-03 20:00:02 |
| chain | chain:1-566 |
| checksum | AE1BE2C8C8E5F867 |
| comment | FUNCTION Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built.SUBUNIT Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex (PubMed:32453425, PubMed:34694004, PubMed:34700328). Associated with ORC2. Interacts with HELB (PubMed:25933514).INTERACTION Associates with chromatin.ALTERNATIVE PRODUCTS Widely expressed, highest levels are found in adult testis and thymus and in fetal liver.DEVELOPMENTAL STAGE Transcript peaks at G1-S transition, but total protein remains constant throughout the cell cycle. Expressed in multiple tissues during embryogenesis, including neural crest-derived structures.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CDC45 family. |
| description | recommendedName: Cell division control protein 45 homolog alternativeName: PORC-PI-1 |
| geneName | CDC45 CDC45L CDC45L2 UNQ374/PRO710 |
| identifier | O75419 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Chromosome Disease variant DNA replication Dwarfism Nucleus Phosphoprotein Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | CDC45 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8961903] ENSEMBL:ENSG00000093009 CDC45 [Homo sapiens] |
| secondaryIdentifier | CDC45_HUMAN B4DDB4 B4DDU3 E9PDH7 O60856 Q20WK8 Q6UW54 Q9UP68 |
| sequenceLength | 566 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8970417] UniProt:O75419-1 CDC45 [Homo sapiens] [ReferenceIsoform:8970418] UniProt:O75419-2 CDC45 [Homo sapiens] [ReferenceIsoform:8970419] UniProt:O75419-3 CDC45 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:68563] CDC45 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O75419 CDC45 (86785)
