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Details on Person UniProt:Q9UJX2 CDC23
| Class:Id | ReferenceGeneProduct:86758 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-597 added on Fri February 6 2015;initiator methionine:1 for 86758 removed on Fri Nov 03 2023;initiator methionine: for 86758 added on Fri Nov 03 2023;initiator methionine: for 86758 removed on Fri Aug 15 2025;initiator methionine:1 for 86758 added on Fri Aug 15 2025 |
| _displayName | UniProt:Q9UJX2 CDC23 |
| _timestamp | 2025-08-15 21:44:00 |
| chain | initiator methionine:1 chain:2-597 |
| checksum | 358F2B8745DB9D32 |
| comment | FUNCTION Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132).PATHWAY Protein modification; protein ubiquitination.SUBUNIT The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5. Interacts with FBXO43; the interaction is direct.INTERACTION Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis.SIMILARITY Belongs to the APC8/CDC23 family. |
| description | recommendedName: Cell division cycle protein 23 homolog alternativeName: Anaphase-promoting complex subunit 8 shortName: APC8 alternativeName: Cyclosome subunit 8 |
| geneName | CDC23 ANAPC8 |
| identifier | Q9UJX2 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Cell cycle Cell division Isopeptide bond Mitosis Phosphoprotein Proteomics identification Reference proteome Repeat TPR repeat Ubl conjugation Ubl conjugation pathway |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CDC23 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996476] ENSEMBL:ENSG00000094880 CDC23 [Homo sapiens] |
| secondaryIdentifier | CDC23_HUMAN A8K6E5 B4E3A2 B7WP05 D3DQB7 O75433 Q53FN2 Q9BS73 |
| sequenceLength | 597 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:145026] UniProt:Q9UJX2-2 CDC23 [Homo sapiens] [ReferenceIsoform:415428] UniProt:Q9UJX2-1 CDC23 [Homo sapiens] [ReferenceIsoform:436020] UniProt:Q9UJX2-3 CDC23 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:174137] CDC23 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174228] CDC23 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UJX2 CDC23 (86758)
