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Details on Person UniProt:Q12834 CDC20

Class:Id	ReferenceGeneProduct:86754
_chainChangeLog	chain:1-499 added on Fri February 6 2015
_displayName	UniProt:Q12834 CDC20
_timestamp	2025-08-15 21:59:24
chain	chain:1-499
checksum	FD5C967AF84089E8
comment	FUNCTION Substrate-specific adapter of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641). Recognizes and binds the destruction box (D box) on protein substrates (PubMed:29343641). Involved in the metaphase/anaphase transition of cell cycle (PubMed:32666501). Is regulated by MAD2L1: in metaphase the MAD2L1-CDC20-APC/C ternary complex is inactive and in anaphase the CDC20-APC/C binary complex is active in degrading substrates (PubMed:9811605, PubMed:9637688). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity).PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of a complex with CDC20, CDC27, SPATC1 and TUBG1 (By similarity). Interacts with NEUROD2 (By similarity). Interacts with dimeric MAD2L1 in its closed conformation form (PubMed:15525512, PubMed:19098431, PubMed:29162720, PubMed:9637688, PubMed:9811605). Interacts with BUB1B (PubMed:15525512, PubMed:18997788, PubMed:19098431, PubMed:33094908). The phosphorylated form interacts with APC/C (PubMed:9637688, PubMed:9734353, PubMed:9811605). Interacts with NINL (PubMed:17403670). May interact with MAD2L2 (PubMed:11459826). Interacts with CDK5RAP2 (PubMed:19282672). Interacts with SIRT2 (PubMed:22014574). Interacts with isoform 1 of NEK2 (PubMed:20034488). Interacts with HSF1 (via phosphorylated form); this interaction occurs in mitosis in a MAD2L1-dependent manner and prevents PLK1-stimulated degradation of HSF1 by blocking the recruitment of the SCF(BTRC) ubiquitin ligase complex (PubMed:18794143). Interacts (via the N-terminal substrate-binding domain) with FBXO5 (By similarity). Interacts with CCNF (PubMed:27653696). Interacts with USP22 (PubMed:27030811).INTERACTION Synthesis is initiated at G1/S, protein level peaks in M phase and protein is abruptly degraded at M/G1 transition.PTM Acetylated. Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C).PTM Phosphorylated during mitosis (PubMed:14657031). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161 (PubMed:15525512). Phosphorylated by NEK2 (PubMed:20034488).PTM Dephosphorylated by CTDP1.PTM Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint (PubMed:18997788, PubMed:19098431). Deubiquitinated by USP44, leading to stabilize the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C (PubMed:17443180). Ubiquitinated at Lys-490 during prometaphase (PubMed:21926987). Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex (PubMed:21926987). Ubiquitinated by UBR5 when not assembled in a multiprotein complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when CDC20 is part of a complex (PubMed:35217622, PubMed:37478862).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the WD repeat CDC20/Fizzy family.CAUTION Originally thought to be phosphorylated by MPF during mitosis. However this paper was retracted due to falsification of data.
description	recommendedName: Cell division cycle protein 20 homolog alternativeName: p55CDC
geneName	CDC20
identifier	Q12834
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Cell cycle Cell division Centromere Chromosome Cytoplasm Cytoskeleton Differentiation Disease variant Isopeptide bond Kinetochore Mitosis Neurogenesis Phosphoprotein Proteomics identification Reference proteome Repeat Ubl conjugation Ubl conjugation pathway WD repeat
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	CDC20
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:9001669] ENSEMBL:ENSG00000117399 CDC20 [Homo sapiens]
secondaryIdentifier	CDC20_HUMAN B2R6Z6 D3DPJ1 Q5JUY4 Q9BW56 Q9UQI9
sequenceLength	499
species	[Species:48887] Homo sapiens
(referenceEntity)	[EntityWithAccessionedSequence:141412] CDC20 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:174112] CDC20 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:6783069] PolyUb-CDC20 [nucleoplasm] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:6783142] ubiquitinylated lysine (PolyUb [nucleoplasm]) at unknown position
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No pathways have been reviewed or authored by UniProt:Q12834 CDC20 (86754)