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Details on Person UniProt:Q13042 CDC16

Class:Id	ReferenceGeneProduct:86748
_chainChangeLog	chain:1-620 added on Fri February 6 2015
_displayName	UniProt:Q13042 CDC16
_timestamp	2024-11-03 20:13:38
chain	chain:1-620
checksum	A9C4F24615DF17EB
comment	FUNCTION Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle (PubMed:18485873). The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132).PATHWAY Protein modification; protein ubiquitination.SUBUNIT V-shaped homodimer. The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5 (PubMed:25043029, PubMed:26083744). Interacts with PPP5C and CDC20 (PubMed:9405394, PubMed:9628895). Interacts with CDC26 (PubMed:19668213). Interacts with FBXO43.INTERACTION Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.ALTERNATIVE PRODUCTS TPR repeats 1-7 mediate homodimerization, while the C-terminal TPR repeats bind to CDC26, burying its hydrophobic N-terminus.PTM Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.SIMILARITY Belongs to the APC6/CDC16 family.
description	recommendedName: Cell division cycle protein 16 homolog alternativeName: Anaphase-promoting complex subunit 6 shortName: APC6 alternativeName: CDC16 homolog shortName: CDC16Hs alternativeName: Cyclosome subunit 6
geneName	CDC16 ANAPC6
identifier	Q13042
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Cell cycle Cell division Cytoplasm Cytoskeleton Mitosis Phosphoprotein Proteomics identification Reference proteome Repeat TPR repeat Ubl conjugation pathway
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
name	CDC16
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8988865] ENSEMBL:ENSG00000130177 CDC16 [Homo sapiens]
secondaryIdentifier	CDC16_HUMAN A2A365 Q5T8C8 Q7Z651 Q96AE6 Q9Y564
sequenceLength	620
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:145024] UniProt:Q13042-2 CDC16 [Homo sapiens] [ReferenceIsoform:145025] UniProt:Q13042-3 CDC16 [Homo sapiens] [ReferenceIsoform:405554] UniProt:Q13042-1 CDC16 [Homo sapiens] [ReferenceIsoform:8966927] UniProt:Q13042-4 CDC16 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:174049] CDC16 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:174156] CDC16 [cytosol] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q13042 CDC16 (86748)