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Details on Person UniProt:O88456 Capns1
| Class:Id | ReferenceGeneProduct:86540 |
|---|---|
| _chainChangeLog | chain:1-269 added on Sat February 7 2015;chain:1-269 for 86540 removed on Wed May 4 2022;chain:1-268 for 86540 added on Wed May 4 2022 |
| _displayName | UniProt:O88456 Capns1 |
| _timestamp | 2023-11-03 16:01:04 |
| chain | chain:1-268 |
| checksum | 49C6DD51FBF5026F |
| comment | FUNCTION Regulatory subunit of the calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Essential for embryonic development (PubMed:10825211).SUBUNIT Homodimer or heterodimer of a large (catalytic) and a small (regulatory) subunit. In presence of calcium, the heterodimer dissociates (By similarity).SUBCELLULAR LOCATION Translocates to the plasma membrane upon calcium binding.DOMAIN The contact of the 5th EF-hand domain from each monomer allows the formation of the homodimer and also appears to mediate the contact between the large catalytic subunit and small regulatory subunit for the formation of the heterodimer.DOMAIN EF-hand domains are paired. EF-hand 1 is paired with EF-hand 2 and EF-hand 3 is paired with EF-hand 4. The fifth EF-hand domain, left unpaired, does not bind the calcium but is responsible of the dimerization by EF-embrace. The first four EF-hand domains bind calcium, however it is not sure if the binding of EF-hand 4 to calcium is physiologically relevant.DISRUPTION PHENOTYPE Embryonic lethality by 11.5 dpc, with indications of defects in both vasculogenesis and erythropoiesis. |
| description | recommendedName: Calpain small subunit 1 shortName: CSS1 alternativeName: Calcium-activated neutral proteinase small subunit shortName: CANP small subunit alternativeName: Calcium-dependent protease small subunit shortName: CDPS alternativeName: Calcium-dependent protease small subunit 1 alternativeName: Calpain regulatory subunit |
| geneName | Capns1 Capn4 |
| identifier | O88456 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Calcium Cell membrane Cytoplasm Membrane Metal-binding Phosphoprotein Reference proteome Repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9773244] Weiser, Joel [InstanceEdit:9796771] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Capns1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CPNS1_MOUSE A0A0R4IZW8 D3YW48 Q3V0X5 Q5BKQ2 Q8CEI2 Q8VEK4 Q9R1C5 |
| sequenceLength | 268 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:8863421] Capns1 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:O88456 Capns1 (86540)
