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Details on Person UniProt:O08529 Capn2
| Class:Id | ReferenceGeneProduct:86522 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;propeptide:2-19 added on Sat February 7 2015;chain:20-700 added on Sat February 7 2015;initiator methionine:1 for 86522 removed on Fri Nov 03 2023;initiator methionine: for 86522 added on Fri Nov 03 2023;initiator methionine: for 86522 removed on Fri Aug 15 2025;initiator methionine:1 for 86522 added on Fri Aug 15 2025 |
| _displayName | UniProt:O08529 Capn2 |
| _timestamp | 2025-08-15 21:36:33 |
| chain | initiator methionine:1 propeptide:2-19 chain:20-700 |
| checksum | 682146B290968316 |
| comment | FUNCTION Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (PubMed:22711986).CATALYTIC ACTIVITY Broad endopeptidase specificity.COFACTOR Binds 7 Ca(2+) ions.ACTIVITY REGULATION Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.SUBUNIT Forms a heterodimer with a small (regulatory) subunit (CAPNS1) (By similarity). Interacts with CPEB3; this leads to cleavage of CPEB3 (PubMed:22711986).SUBCELLULAR LOCATION Translocates to the plasma membrane upon Ca(2+) binding.TISSUE SPECIFICITY Ubiquitous.SIMILARITY Belongs to the peptidase C2 family. |
| description | recommendedName: Calpain-2 catalytic subunit ecNumber: 3.4.22.53 alternativeName: 80 kDa M-calpain subunit shortName: CALP80 alternativeName: Calcium-activated neutral proteinase 2 shortName: CANP 2 alternativeName: Calpain M-type alternativeName: Calpain-2 large subunit alternativeName: Millimolar-calpain shortName: M-calpain |
| geneName | Capn2 |
| identifier | O08529 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Calcium Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Protease Reference proteome Repeat Thiol protease |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2587579] Weiser, JD [InstanceEdit:5263031] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Capn2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CAN2_MOUSE O35518 O54843 |
| sequenceLength | 700 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:8863424] Capn2 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:O08529 Capn2 (86522)
