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Details on Person UniProt:O35350 Capn1
| Class:Id | ReferenceGeneProduct:86518 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-713 added on Sat February 7 2015 |
| _displayName | UniProt:O35350 Capn1 |
| _timestamp | 2023-11-03 16:18:56 |
| chain | chain:1-713 |
| checksum | 3E1E26C95802B864 |
| comment | FUNCTION Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-375', 'Gly-388' and 'His-410'. Cleaves and activates caspase-7 (CASP7).CATALYTIC ACTIVITY Broad endopeptidase specificity.COFACTOR Binds 4 Ca(2+) ions.ACTIVITY REGULATION Activated by micromolar concentrations of calcium and inhibited by calpastatin.SUBUNIT Forms a heterodimer with a small (regulatory) subunit CAPNS1.SUBCELLULAR LOCATION Translocates to the plasma membrane upon Ca(2+) binding.PTM Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity).SIMILARITY Belongs to the peptidase C2 family. |
| description | recommendedName: fullName evidence="6"Calpain-1 catalytic subunit ecNumber evidence="2"3.4.22.52 alternativeName: fullName evidence="2"Calcium-activated neutral proteinase 1 shortName evidence="2"CANP 1 alternativeName: fullName evidence="2"Calpain mu-type alternativeName: fullName evidence="2"Calpain-1 large subunit alternativeName: Micromolar-calpain shortName evidence="2"muCANP |
| geneName | Capn1 Canp1 Capa1 |
| identifier | O35350 |
| isSequenceChanged | FALSE |
| keyword | Autocatalytic cleavage Calcium Cell membrane Cytoplasm Hydrolase Membrane Metal-binding Phosphoprotein Protease Reference proteome Repeat Thiol protease |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:2455454] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8934940] Weiser, JD [InstanceEdit:8987656] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9715482] Weiser, JD [InstanceEdit:9819394] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Capn1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CAN1_MOUSE O88666 |
| sequenceLength | 713 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:8863423] Capn1 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:O35350 Capn1 (86518)
