Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P62152 Cam
| Class:Id | ReferenceGeneProduct:86489 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-149 added on Sat February 7 2015;initiator methionine:1 for 86489 removed on Fri Nov 03 2023;initiator methionine: for 86489 added on Fri Nov 03 2023;initiator methionine: for 86489 removed on Fri Aug 15 2025;initiator methionine:1 for 86489 added on Fri Aug 15 2025 |
| _displayName | UniProt:P62152 Cam |
| _timestamp | 2025-08-15 21:28:39 |
| chain | initiator methionine:1 chain:2-149 |
| checksum | 6B44A8917FC7027B |
| comment | FUNCTION Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (By similarity). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (By similarity). In photoreceptor cells, light-induced Ca(2+) influx activates calmodulin, which in turn is likely to promote Crag activity in trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes (PubMed:23226104). Together with Akap200, regulates PKA activity and ethanol-induced sensitivity and tolerance (PubMed:10480937, PubMed:29444420).SUBUNIT Interacts with Crag (PubMed:18331716). Interacts with stac (PubMed:9813038). Interacts with Akap200; the interaction is calcium-dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937).INTERACTION Trimethylation of Lys-116 observed in other calmodulins is absent here, but does occur at Lys-95 specifically in the compound eye.DISRUPTION PHENOTYPE RNAi-mediated knockdown in the perineurial glia increases ethanol sedation resistance and decreases ethanol tolerance.MISCELLANEOUS This protein has four functional calcium-binding sites.MISCELLANEOUS Two alternative gene models exist that generate identical translations.SIMILARITY Belongs to the calmodulin family. |
| created | [InstanceEdit:84067] Schmidt, EE, 2003-12-18 04:29:09 |
| description | recommendedName: Calmodulin shortName: CaM |
| geneName | Cam CG8472 |
| identifier | P62152 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Calcium Cytoplasm Metal-binding Methylation Reference proteome Repeat |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3132113] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9627708] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | Cam |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CALM_DROME P07181 Q9V3T4 |
| sequenceLength | 149 |
| species | [Species:56210] Drosophila melanogaster |
| (referenceEntity) | [EntityWithAccessionedSequence:426962] CAM [cytosol] [Drosophila melanogaster] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P62152 Cam (86489)
