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Details on Person UniProt:P97678 Kcnmb1
| Class:Id | ReferenceGeneProduct:86466 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-191 added on Fri February 6 2015 |
| _displayName | UniProt:P97678 Kcnmb1 |
| _timestamp | 2023-11-03 16:22:43 |
| chain | chain:1-191 |
| checksum | D39F2FE4D69D7662 |
| comment | FUNCTION Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate (By similarity).SUBUNIT Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB1 per KCNMA1 tetramer (By similarity).SUBCELLULAR LOCATION Weakly expressed. In brain, it is expressed in a few discrete populations of neurons that also express KCNMA1.PTM N-glycosylated.SIMILARITY Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB1 subfamily. |
| description | recommendedName: Calcium-activated potassium channel subunit beta-1 alternativeName: BK channel subunit beta-1 shortName: BKbeta shortName: BKbeta1 alternativeName: Calcium-activated potassium channel, subfamily M subunit beta-1 shortName: Calcium-activated potassium channel subunit beta alternativeName: Charybdotoxin receptor subunit beta-1 alternativeName: K(VCA)beta-1 alternativeName: Maxi K channel subunit beta-1 alternativeName: Slo-beta-1 shortName: Slo-beta alternativeName: Slowpoke-beta |
| geneName | Kcnmb1 |
| identifier | P97678 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Glycoprotein Ion channel Ion transport Membrane Reference proteome Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9027688] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | Kcnmb1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | KCMB1_RAT O35337 O88805 Q9ESK7 Q9QWI7 |
| sequenceLength | 191 |
| species | [Species:48895] Rattus norvegicus |
| (isoformParent) | [ReferenceIsoform:145515] UniProt:P97678-2 Kcnmb1 [Rattus norvegicus] [ReferenceIsoform:145516] UniProt:P97678-3 Kcnmb1 [Rattus norvegicus] [ReferenceIsoform:404941] UniProt:P97678-1 Kcnmb1 [Rattus norvegicus] |
| (referenceEntity) | [EntityWithAccessionedSequence:9667755] Kcnmb1 [plasma membrane] [Rattus norvegicus] |
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No pathways have been reviewed or authored by UniProt:P97678 Kcnmb1 (86466)
